Skip to content

SPIRE HANDBOOKSLAY THE SPIRE 2

Builds Characters Cards Relics Potions Challenges Runs Guides

Home/Relics/Royal Poison

Royal Poison artwork

Relics

Royal Poison

Rarity: Event Relic
Pool: Shared

Effect

At the start of each combat, lose 4 HP.

Main branchLast updated 2026-11-02

Royal Poison (relic)/images/relics/royal_poison.webpAt the start of each combat, lose 4 HP.

Sources

Last updated 2026-11-02.

Game reference data: main branch

An independent Slay the Spire 2 strategy reference.

Game artwork and game data © Mega Crit. Extracted reference data and images via Spire Codex.

Build comparison Combat decisions Unusual builds Challenge routes Recorded runs Enemies Events & Ancients Gameplay guides Achievements & badges Version changes Official game ↗