Decisions and interactions
AccelerantIf an enemy has nine Poison, an ordinary trigger loses nine HP and reduces the stack to eight.
Snecko SkullIts bonus is 1 extra Poison per application, rather than 1 extra Poison per card or a multiplier to the entire stack.
Potion of DoomPotion of Doom can accelerate the Doom build before its cards have built a large stack.
Silent Poison and AccelerantEach trigger also reduces Poison, so faster damage spends the stack faster.
Necrobinder Doom and defensive triggersIts payoff is tied to applications, not merely to the size of a single stack.
Doom versus Poison: damage, debuffs and the last enemy attackTime's Up converts the existing Doom amount into damage, creating another way to use the stack before the normal check.